Postdoctoral Position Neural Mechanisms of Learning in Drosophila Larvae

Our lab is dedicated to understanding the neural mechanisms underlying learning and behaviour in Drosophila larvae. The primary brain structure involved in learning in Drosophila is called the mushroom bodies, which is organized into multiple functional compartments. Our lab has recently published the full connectome of the larval brain, uncovering the complex and highly recurrent connectivity map of the mushroom bodies. In addition, previous work from our lab and others has shed light on basic rules of plasticity of some of the mushroom bodies' compartments. However, the precise functional role of each compartment remains largely unknown.

This project aims to investigate learning in Drosophila larvae using natural odour paradigms. The successful candidate will employ a novel Y-maze behavioural setup to assess various learning protocols and determine how different experimental parameters influence learning performance. In parallel, the project will leverage a new imaging system to visualize activity and plasticity in mushroom body neurons in response to learning.

By integrating behavioural assays with high-resolution neural imaging, this work seeks to provide deeper insight into how learning is compartmentalized within the mushroom bodies and how these circuits are modulated during experience-dependent plasticity.

Candidate Profile

The ideal candidate will:

• Hold a PhD in neurobiology or a related field.
• Have demonstrated experience working with Drosophila, particularly in the context of behavioural learning assays.
• Preferably have experience with Y-maze paradigms or similar behavioural set-ups.
• Be proficient in microscopy techniques used for imaging neuronal activity or structure.
• Have a strong engineering background and experience in coding to support, maintain, and further develop custom-built behavioural and imaging systems.
• Be a motivated and interdisciplinary researcher who enjoys working at the interface of behaviour, neurobiology, and technology.

Fixed term: The funds for this post are available for up to 2 years in the first instance.

The closing date for applications is 25th September 2025.

Interviews are likely to take place in the week commencing Monday 6th October 2025 and may be conducted remotely under exceptional circumstances.

Informal enquiries are welcomed and should be directed to: Dr Marta Zlatic (mz209@cam.ac.uk)

If you have any queries regarding the application process, please contact Paulina Lasocka (pl585@cam.ac.uk)

Please quote reference PF47231 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.