Research Associate

Imperial College London - Faculty of Medicine - Department of Brain Sciences

Location: London, Hybrid

Salary: £49,017 to £57,472 per annum

Hours: Full Time

Contract Type: Fixed-Term/Contract

Placed On: 23rd September 2025

Closes: 1st October 2025

Job Ref: MED05425

About the role

The Barnes Lab is recruiting a postdoctoral research associate to use multiplexed synaptic proteomics to investigate how synaptic molecular complexity impacts synaptic function in health and early-stages of Alzheimer’s disease.

We have an exciting role for a motivated Research Associate in synaptic molecular complexity in health and disease to join the Group of Dr Samuel Barnes. Dr Barnes’ research focuses on homeostatic plasticity mechanisms that regulate neural firing-rate activity within a stable dynamic range, preventing prolonged periods of hyper- or hypo-activity. You will be given opportunities to train in new methods, develop new competencies relevant to the specific aims set and address major questions of importance for Alzheimer’s disease and related neurodegenerative conditions. The project focuses on multiplexed synaptic proteomics to investigate how synaptic molecular complexity impacts synaptic function in health and early-stages of Alzheimer’s disease. The role will involve collection of data using in vivo 2-Photon imaging, confocal imaging, expansion microscopy and cycle immunofluorescence approaches. A good background in neuroscience, data analysis and coding are essential. You will be expected to publish work and deliver presentations and will be supported to apply for independent internationally competitive fellowships.

The UK is well placed to play a leading role in this revolution due to its scientific strengths in the field, led by the UK Dementia Research Institute (UK DRI) working with our world-class, university-based centres. We are a globally leading multidisciplinary research institute of over 900 staff investigating the spectrum of neurodegenerative disorders causing dementia, driving a step change in our understanding of neurodegeneration, and accelerating the discovery, development and delivery of interventions that will help diagnose, treat, and ultimately prevent dementia.

What you would be doing

The role will involve collection of data using in vivo 2-Photon imaging, confocal imaging, expansion microscopy and cycle-immunofluorescence approaches. A good background in neuroscience, data analysis and coding are essential. You will be expected to publish work, deliver presentations and contribute to funding application, leading where appropriate.

What we are looking for

You will be highly motivated and excited by the science with a background in neuroscience and experience in neuronal imaging technologies, and looking to use this role as a springboard toward securing an internationally competitive fellowship. You will have a track record of delivering high impact publications on AD-related pathogenesis and/or a related research area.

What we can offer you

Working with the UK Dementia Research Institute and collaborators; State-of-the-art equipment infrastructure; Benefit from sector-leading salary and remuneration package (including 39 days off a year and generous pension schemes); Get access to a range of workplace benefits including a flexible working policy from day 1, generous family leave packages, on-site leisure facilities and a cycle-to-work scheme; Interest-free season ticket loan schemes for travel; Be part of a diverse, inclusive, and collaborative work culture with various staff networks and resources designed to support your personal and professional wellbeing.

Further information

This is a Full time, Fixed term contract based at our Hammersmith Campus. For informal enquiries please contact Dr Samuel Barnes attaching your CV via email samuel.barnes@imperial.ac.uk

Closes: 01 October 2025