"Research Technician ? Fischer Lab"

The Fischer Lab at Dana-Farber Cancer Institute is a Structural and Chemical Biology laboratory that combines a broad range of experimental and computational approaches to study protein homeostasis pathways and disease-relevant protein complexes, particularly those associated with cancer. Using deep expertise in cellular degradation machinery, we apply structure- and computation-guided strategies to develop and test novel small molecules that hijack the ubiquitin-proteasome system for targeted protein degradation. By integrating fundamental mechanistic insight with translational chemical biology, we are pioneering new therapeutic strategies with direct relevance to cancer treatment.

The Fischer Lab (https://fischerlab.dana-farber.org/) seeks a highly motivated individual to join the team as a Research Technician. The successful candidate will work closely with a senior postdoctoral fellow to advance multiple ongoing research projects focused on pediatric cancer therapeutics. The successful candidate can develop an independent project if there is interest. The role is bench-intensive and central to the lab’s scientific progress.

In addition to experimental research, responsibilities include selected aspects of laboratory management and organization.

A research technician will provide additional training and structured support during the transition period. Training is available across all major experimental platforms in the laboratory.

This position offers the opportunity to contribute directly to innovative, therapeutically driven research in a highly collaborative environment with immediate translational impact in oncology.

RESPONSIBILITIES:

1. Responsible for technical assistance with multiple projects related to cancer therapeutics
2. Performs protein expression and purification procedures
3. Conduct standardized biological or biochemical assays and laboratory analyses, eg. TR-FRET, FP, pull downs, cell-based assays, western blot, flow cytometry
4. Analyzes experimental data and interpret results to write reports, presentations, grant and publication preparation
5. Uses computers, computer-interfaced equipment, robotics or high-technology applications to perform work duties.
6. Maintains detailed notebook of all work-related activities
7. Operation and maintenance of standard lab equipment
8. Maintains and orders laboratory supplies
9. Communicates with purchasing and may be responsible for negotiating with vendors
10. Prepares lab reagents and media

KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED:

1. Knowledge of information and techniques related to biology and molecular biology
2. Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff
3. Ability to analyze information and use logic to address work-related issues and problems
4. Must have attention to detail and be thorough in completing work tasks
5. Ability to work within a team environment

MINIMUM JOB QUALIFICATIONS:

1. Bachelor's Degree required with a major in biology, chemistry or "pre-med" preferred.
2. Master in biochemistry or related field preferred.
3. Research experience in molecular biology or biochemistry
4. Ability to analyze information and use logic to address work-related issues and problems.
5. Must have close attention to detail and consistent work habits.
6. Ability to work within a team environment.
7. A minimum time commitment of 2 years is preferred.