Structural Mass Spectrometry Scientist

University of Leeds - Astbury Centre for Structural Molecular Biology / Faculty of Biological Sciences

Placed On: 14th October 2025

Closes: 27th October 2025

Job Ref: FBSMB1306

This role will be based on the university campus. We are open to discussing flexible working arrangements.

Are you looking for a role to utilise and develop your mass spectrometry skills within the context of a world-class mass spectrometry facility? Do you want to work with a broad group of scientists from academia and industry? Do you have a passion for transformational biological and biomedical discovery, and delivering cutting edge outputs where the generation and analysis of data play a key role?

We are looking for a structural mass spectrometry (MS) scientist to join our facility team within the Faculty of Biological Sciences and the Astbury Centre for Structural Molecular Biology. Working with state-of-the-art equipment and utilising your expertise in the field, you will work on multiple projects as a structural mass spectrometry expert in hydrogen-deuterium exchange-MS, native MS, chemical crosslinking-MS, and various top-down and bottom-up proteomics approaches. You will provide expert guidance, training and advice in areas covering sample preparation, optimisation, method development, data acquisition, and data interpretation.

You should have, or be close to completing, a PhD in chemistry, biochemistry, analytical science, structural molecular biology or related discipline, and experience of at least one structural MS method, and have a passion for studying biological mechanisms relevant to human disease. You will work closely, interactively and collaboratively with the facility team as well as the wider MS community and external partners, and so excellent verbal and written communication and interpersonal skills are essential.

The Astbury Centre for Structural Molecular Biology (ACSMB) in Leeds provides an outstanding environment to undertake cutting-edge research. ACSMB is an interdisciplinary research hub focused on understanding life in molecular detail. ACSMB has >70 academic members, a grant portfolio of >110m, and expertise in physics, chemistry, medicine and biology. ACSMB hosts state-of-the-art facilities for MS, cryo-EM, crystallography, NMR (including 950MHz), protein production, single molecule force spectroscopy, microscopy, biomolecular interactions and biophysics. ACSMB provides a vibrant environment for structural molecular and cellular biology, with experts in biophysics and structure, chemical biology, membrane biology, virology, enzymology and bioinformatics.

Salary Requirements of the Skilled Worker Visa Route

Please note that this post may be suitable for sponsorship under the Skilled Worker visa route but first-time applicants might need to qualify for salary concessions. For more information please visit: www.gov.uk/skilled-worker-visa.

For research and academic posts, we will consider eligibility under the Global Talent visa. For more information please visit: https://www.gov.uk/global-talent

To explore the post further or for any queries you may have, please contact: Dr Sri Ranjani Ganji, Mass Spectrometry Facility Manager Email: s.r.ganji@leeds.ac.uk