Rate My Professor Elly Ngan

Her research specializes in molecular and cellular biology, disease modeling, and neural crest cell development, with a focus on Hirschsprung disease and neuroblastoma. She has developed human pluripotent stem cell-based models, including iPSC and organoids, to investigate the functional impacts of Hirschsprung-associated mutations on enteric nervous system development. Key publications include 'Correction of Hirschsprung-associated Mutations in Human Induced Pluripotent Stem Cells via CRISPR/Cas9, Restores Neural Crest Cell Function' (Gastroenterology, 2017), 'Identification of GLI Mutations in Patients with Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice' (Gastroenterology, 2015), 'Prokineticin signaling is required for the maintenance of a de novo population of c-KIT+ cells to sustain neuroblastoma progression' (Oncogene, 2015), and 'Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans' (Journal of Clinical Investigation, 2011). With 63 publications in high-impact journals such as PNAS, JCI, and Oncogene, her work has garnered over 3,000 citations. Ngan serves as an editor for Scientific Reports, chairs international meetings, reviews for over 20 journals and grant agencies, and delivered a keynote lecture at the Nobel Forum of Karolinska Institute.