Rate My Professor Lan Huang

Huang's research centers on biological mass spectrometry and proteomics, specializing in cross-linking mass spectrometry to study protein complexes, posttranslational modifications, protein-protein interactions, and ubiquitin-proteasome degradation pathways. These pathways control essential cellular functions including cell cycle progression, apoptosis, and DNA repair, with disruptions linked to cancer and neurodegenerative diseases. Her lab has developed innovative MS-cleavable crosslinkers for accurate identification of cross-linked peptides. Key publications include "Development of a novel cross-linking strategy for fast and accurate identification of cross-linked peptides of protein complexes" (Molecular & Cellular Proteomics, 2011), "Cross-linking mass spectrometry (XL-MS): an emerging technology for interactomics and structural biology" (Analytical Chemistry, 2017, 416 citations), "Oxidative stress-mediated regulation of proteasome complexes" (Molecular & Cellular Proteomics, 2011, 451 citations), and "Regulation of the 26S Proteasome Complex During Oxidative Stress" (Science Signaling, 2010, 323 citations). She received the Excellence in Graduate Teaching Award in 2021 for Introduction to Proteomics and is an Associate Editor for Molecular & Cellular Proteomics. Her work advances proteomics for structural biology and therapeutic targets in cancer and Alzheimer's disease.