Postdoctoral Fellowship in Mitochondrial Peroxiredoxins

Is the Job related to staff position within a Research Infrastructure?: No

Offer Description

The Laboratory of Protein and Redox Biology at the Institute of Biosciences, University of São Paulo (IB-USP), Brazil, invites applications for a FAPESP-funded postdoctoral position to investigate the localization and functions of mitochondrial peroxiredoxins (Prxs) in oxidative stress responses and redox signaling.

The main objectives of the project are to understand: (i) the mechanisms that target Prxs to the mitochondrial matrix and intermembrane space (IMS); (ii) how Prxs localized in these compartments regulate peroxide homeostasis, including H₂O₂; and (iii) the physiological functions of these proteins in the mitochondrial matrix and IMS. Redox status and mitochondrial function will be investigated using yeast and human cell models, with a particular focus on ScPrx1 and human Prdx3, and with the aim of establishing potential connections with processes related to cancer and ferroptosis.

The successful candidate will have the opportunity to work in an interdisciplinary research environment combining approaches in molecular biology, biochemistry, cell biology, and redox biology.

How to Apply

Applicants should submit:

• Curriculum vitae (FAPESP Summary Curriculum Vitae format), including a complete list of scientific publications;
• Motivation letter describing previous experience relevant to the project and interest in the position;
• A copy of the Ph.D. thesis;
• Names and two letters of recommendation.

Applications should be submitted by e-mail with the subject line:

“Application – FAPESP – funded Postdoctoral Fellowship in Mitochondrial Peroxiredoxins”

For further information and to submit your application, please contact:

Prof. Luis Eduardo Soares Netto

Institute of Biosciences – University of São Paulo (USP)

São Paulo, Brazil

E-mail: nettoles@ib.usp.br

Where to apply

E-mail: nettoles@ib.usp.br

Requirements

Research Field: Biological sciences » Biology

Education Level: PhD or equivalent

Skills/Qualifications

Required Qualifications

• Ph.D. in Biological Sciences, Biochemistry, Molecular Biology, or a related field, obtained within the last 7 years;
• Demonstrated experience in experimental laboratory research;
• Experience with molecular biology and biochemical techniques, including Western blotting;
• Experience with cell culture and cell manipulation;
• Experience with genetic techniques and/or manipulation of experimental models;
• Ability to analyze and interpret experimental data;
• Strong academic record and experience in scientific writing, demonstrated by a publication record in the field or related areas.

Desirable Qualifications

• Experience with redox proteins, peroxiredoxins, H₂O₂ metabolism, and/or mitochondrial biology;
• Experience with yeast and/or mammalian cell models;
• Experience with subcellular fractionation and protein localization studies;
• Knowledge of or experience with genetically encoded redox sensors and/or fluorescence microscopy;
• Ability to work independently and collaboratively in an interdisciplinary research team;
• Interest in contributing to the training and supervision of undergraduate and graduate students.

Specific Requirements: please, see above

Languages: ENGLISH

Level: Excellent

Additional Information

Work Location(s)

Number of offers available: 1

Company/Institute: University of Sao Paulo/Institute of Biosciences

Country: Brazil

State/Province: São Paulo

City: São Paulo

Postal Code: 05351015

Street: Rua do Matao 277

Contact

State/Province: São Paulo

City: São Paulo

Website: https://www.ib.usp.br/

Street: Rua do Matao 277

Postal Code: 05351015