"Postdoctoral Research Associate in Biochemistry and Structural biology"

Postdoctoral Research Associate in Biochemistry and Structural biology

University of Oxford - Department of Biochemistry

Location:OxfordSalary:£41,997 to £46,913 per annumHours:Full TimeContract Type:Fixed-Term/ContractPlaced On:13th August 2025Closes:15th September 2025Job Ref:181497

About the role

Dr. Frank Bürmann leads a research group investigating the molecular mechanisms of chromosome remodelling. The team employs biochemical reconstitution, electron cryomicroscopy (cryo-EM), advanced bacterial genetics, and phage biology to explore how cells and viruses control the three-dimensional structure of DNA. We investigate how structural maintenance of chromosomes (SMC) complexes shape chromosomes by DNA loop extrusion, how they cooperate with DNA topoisomerases, and how bacteriophages and other infectious agents manipulate host chromosomes and defences.

We are seeking a motivated and skilled Postdoctoral Research Associate in biochemistry and structural biology to join our expanding team. This is an exciting opportunity to contribute to pioneering research at the forefront of structural chromosome biology. You will investigate the molecular mechanisms of SMC complexes using cryo-EM, with the aim of directly visualising their activities. You will employ a multi-disciplinary approach, including protein/nucleic acid biochemistry, bacterial genetics, and phage biology to test and generate hypotheses. You will develop new ideas and approaches and provide guidance to less experienced members of the team.

This full-time fixed-term post is funded by the Wellcome Trust for up to 3 years in the first instance and is based at the Department of Biochemistry, South Parks Road, Oxford.

The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available.

About you

You will hold a PhD/DPhil or be near completion of a PhD/DPhil in a relevant biological discipline. Good communication and documentation skills, and the ability to work effectively as part of a team are essential. You will be self-motivated, creative, and persistent, with a proven ability to address challenging research questions. You will have experience in protein chromatography, recombinant DNA techniques, and quantitative data analysis. The research involves cryo-EM sample preparation, data acquisition, and analysis, so experience in these areas would be advantageous.

What We Offer

Your happiness and wellbeing at work matters to us, so we offer a range of family friendly and financial benefits including:

• An excellent contributory pension scheme
• 38 days annual leave
• A comprehensive range of childcare services
• Family leave schemes
• Cycle loan scheme
• Membership to a variety of social and sports clubs
• Discounted bus travel and Season Ticket travel loans

The University also runs an enormous amount of social groups and sports clubs for those looking for more than just a great place to work.

Application Process

Applications for this vacancy are to be made online via the 'Apply' button above and Vacancy ID 181497. You will be required to upload your curriculum vitae and a supporting statement, setting out how you meet the selection criteria for the post, using examples of your skills and experience. Click here for information and advice on writing an effective Supporting Statement. As part of your application, you will be asked to provide details of two referees and indicate whether we can contact them now.

For further details, please refer to the How to apply section of the job description. Any further enquires may be directed to recruitment@bioch.ox.ac.uk.

The closing date for applications is 12.00 noon on Monday 15th September 2025. Only applications received before this time can be considered. Interviews for shortlisted candidates to be held as soon as possible thereafter.