Research Assistant in Mass Spectrometry Based Proteomics

University of Oxford - Centre for Medicines Discovery

Location: NDM Research Building, Old Road Campus, Headington, Oxford, OX3 7FZ

Salary: Standard Grade 6: Salary in range £35,681 - £41,636 per annum (pro rata). This is inclusive of a pensionable Oxford University Weighting of £1,730 per year (pro rata).

We are seeking to appoint a Research Assistant in mass spectrometry-based proteomics to join the Clinical Research Group led by Professor Roman Fischer at Centre for Medicines Discover Nuffield Department of Medicine.

The group focuses on single-cell, spatial, and high-throughput clinical proteomics with applications in patients’ tissue and blood samples across multiple pathologies. This position supports Go-PRECISE, a major collaborative project funded by GSK and the Department of Oncology, which aims to characterise the early stages of diseases such as ovarian and lung cancer to support the development of cancer vaccines. You will play an active role in the acquisition and analysis of spatial and single-cell proteomic data from patient biopsies, and in supporting immunopeptidomics workflows for vaccine discovery.

You will be responsible for preparing and processing biological samples for mass spectrometry, operating high-end MS instrumentation, and performing data analysis using proteomics software and statistical tools. You will participate in the daily operation and maintenance of MS and liquid-handling equipment, monitor project progress and sample tracking, and contribute to method development for spatial and high-throughput proteomics. Accurate record keeping, adherence to quality control standards, and the ability to analyse and present data clearly will be key aspects of your work. You will also supervise mass spectrometry and liquid handling equipment.

It is essential that you hold a degree on a life-science related subject together with relevant experience in wet lab work/biochemistry. You should have a careful, methodical approach to experimental work, strong organisational skills, and excellent attention to detail. The ability to communicate effectively, work well as part of a team, and manage multiple tasks simultaneously is essential. Prior experience in proteomics sample preparation and instrument control is highly desirable.

Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.

This position is offered full time on a fixed term contract for 31 December 2027 and is funded by Go-Precise.

Only applications received before 12 midday on Thursday 20 November 2025 will be considered. Please quote 183164 on all correspondence.