Research Associate in Systems Immunology

King's College London - Peter Gorer Department of Immunobiology

About Us

We are seeking a highly motivated Postdoctoral Research Associate with expertise in bioinformatics, systems immunology, or computational biology to join the Translational Immunobiology of Critical Illness research group led by Manu Shankar-Hari at King's College London.

About the role

This post focuses on systems immunology approaches to tackle a global healthcare challenge: sepsis.

This position forms part of a multidisciplinary programme investigating how dysregulated immune responses drive sepsis and other forms of critical illness, with the goal of identifying novel biomarkers and precision immunotherapy strategies to improve patient outcomes. More information about the research group can be found here.

The groups’ programmatic work focuses on understanding how immune dysregulation drives sepsis and other forms of critical illness, with the goal of identifying molecular mechanisms, biomarkers, and potential precision immunotherapy strategies. Working closely with clinicians and immunologists, the postholder will apply advanced analytical approaches to uncover immune signatures associated with disease heterogeneity and patient outcomes.

This role provides an excellent opportunity to develop an independent research profile, contribute to translational discoveries in sepsis, and gain experience with multi-omics and computational approaches in an inter-disciplinary research environment.

The post-holder will analyse and integrate multi-omics datasets, including transcriptomics, proteomics, metabolomics, and single-cell data, generated from well-characterised cohorts of critically ill patients with sepsis. Using advanced computational approaches, the postholder will investigate the molecular immune mechanisms underlying sepsis, with the aim of informing patient stratification, biomarker discovery, and precision medicine.

This role will involve close collaboration with clinicians, and immunologists, to translate bioinformatic discoveries into clinically meaningful outputs. Experience in the analysis of complex multi-omics datasets and systems immunology approaches would be advantageous. The successful applicant will demonstrate strong communication skills and an enthusiasm for developing novel computational approaches to advance our understanding of sepsis immunopathology.

Candidates with a strong interest in translational immunology and data-driven approaches to understanding sepsis biology are particularly encouraged to apply.

The post will be based at Guy's Hospital and provides access to state-of-the-art core facilities, including genomics, multi-omics platforms, and high-performance computing resources. You will also engage with wider collaborative initiatives that enhance the translational impact of your research.

This is a full-time post (35 hours per week), and you will be offered a fixed term contract for 36 months.