"Research Specialist A/B"

Job Description Summary

We are seeking a highly motivated and enthusiastic individual with a strong background in computational biology to join our team. The successful candidate will contribute to publication-driven projects focused on understanding immune dysregulation in autoimmune diseases and identifying novel biomarkers for type 1 diabetes (T1D). Responsibilities include T cell stimulation, antibody staining, cell sorting, constructing bulk and single-cell sequencing libraries, performing RNA-seq, antibody-seq, TCR-seq, and BCR-seq data analyses and integration using R or Python. The ideal candidate will have experience with flow cytometry, track records of bulk and single-cell RNA, TCR, and BCR sequencing data analysis, proficiency in advanced quantitative statistical methods, and a solid understanding of adaptive immunity, particularly T cell biology. Strong communication and organizational skills are essential, and the ability to work collaboratively within a team is critical. This position offers a high degree of independence, opportunities for project leadership, and the chance to contribute to cutting-edge translational immunology research in a supportive and collaborative environment.

Job Responsibilities

Research Specialist A:

• Perform blood/tissue sample processing and assist with sample management
• Maintain cells in culture and perform T cell stimulation
• Perform antibody staining and analyses of cells on flow cytometer
• Assist with preparation of sequencing libraries and coordinate sample submission for sequencing
• Perform data preprocessing, batch effect correction, and basic analyses of sequencing data.

Research Specialist B

In addition to the duties outlined under Research Specialist A, Research Specialist B will be able to independently sort cells and prepare sequencing libraries. Will also carry out advanced downstream analyses of RNA, antibody, TCR, and BCR sequencing datasets.

Position Contingent Upon Funding

Qualifications

Research Specialist A

Bachelor of Science and 0 to 1 year of experience or equivalent combination of education and experience is required.

Preferred:

• Basic computational skills in R and/or Python
• Have working knowledge of tissue culture and flow cytometry to be able to perform T cell stimulation, antibody staining, and FACS analyses.
• Solid understanding of adaptive immunity, especially T cell biology
• Strong communication skills and ability to work effectively in a collaborative team environment
• Excellent organizational skills and attention to detail

Research Specialist B

Bachelor of Science and 1 to 2 years of experience or equivalent combination of education and experience is required.

In addition to qualifications outlined under Research Specialist A, Research Specialist B will have advanced computational skills in R and/or Python, have demonstrated experience analyzing bulk and single cell sequencing data, be able to use statistical/machine learning methods to solve problems, and perform cell sorting and other immunological techniques.

Job Location

Philadelphia, Pennsylvania

Department / School

Perelman School of Medicine

Pay Range

$44,500.00 - $57,335.40 Annual Rate