Job Information
Organisation/Company: Institute of Human Genetics of the Polish Academy of Sciences
Research Field: Biological sciences » Biology
Researcher Profile: Recognised Researcher (R2)
Positions: Postdoc Positions
Application Deadline: 9 Sep 2026 - 23:59 (Europe/Warsaw)
Country: Poland
Type of Contract: To be defined
Job Status: Full-time
Hours Per Week: 40
Offer Starting Date: 1 Nov 2026
Is the job funded through the EU Research Framework Programme?: Other EU programme
Reference Number: SONATA BIS 2023/50/E/NZ1/00233
Is the Job related to staff position within a Research Infrastructure?: No
Offer Description
The characteristic feature of several B-cell lymphomas are translocations involving the immunoglobulin heavy chain (IGH) locus and oncogenes such as MYC, BCL2, BCL6, CCND1. As a result, the translocated oncogenes are placed under the control of IGH enhancers (Eµ, 3’RR1 and 3’RR2) which drive their expression and lymphomagenesis. In our previous study we identified exact regions in IGH enhancers critical for lymphoma cell growth and confirmed transcription of enhancer RNAs (eRNA) from these regions in cell lines and patients.
The goal of this project is to develop a novel therapeutic approach for B-cell lymphoma based on targeting the IGH enhancer RNA. To this end, we will conduct a high-throughput screening for small molecules binding to the eRNA transcribed from the essential region in the IGH enhancers. Next, hit compounds will be validated for their effect on lymphoma cell growth and potential toxicity towards normal cells. Finally, selected compounds will be assessed in vivo in mouse xenograft models.
Results of our project will indicate novel therapeutic opportunities for treatment of B-cell lymphomas. Our strategy will universally target IGH translocations, regardless of the oncogene involved. This may be especially relevant for the group of so-called double hit B-cell lymphoma patients (with two oncogenes translocated to IGH), who in general respond poorly to current treatment regimens. Results of this pre-clinical proof of concept study will provide novel B-cell lymphoma therapeutics with a direct translation to clinical studies.
Key responsibilities:
- Active participation in the implementation of experimental tasks of the project (validation of the identified hit compounds in lymphoma cell lines: cell culture, molecular analyses and functional studies, assessment of efficacy and safety in vivo in mouse xenograft models) and analysis of results.
- Presentation of results at seminars and conferences and participation in writing scientific publications.
- Writing review papers.
- Supervision of students.
Where to apply
Website: http://bip.igcz.poznan.pl/konkurs/
Requirements
Research Field: Biological sciences » Biology
Education Level: PhD or equivalent
Skills/Qualifications
- PhD degree in the field of in biological, chemical or medical sciences, obtained no earlier than in 2018 (this period may be extended by the time spent on leave related to the care and upbringing of the child).
- Knowledge and skills in molecular biology.
- Scientific achievements in the form of publications in the field of biological and/or medical sciences.
- Fluent knowledge of English in speech and writing.
- Independence, high motivation for work in science, problem solving.
- Ability to teamwork.
- Experience in cell culture and working with animals will be an additional asset.
- During the employment period, the Employee will not receive any other remuneration from the funds allocated as direct costs from research projects financed under NCN calls.
- During the employment period, the Employee will not receive remuneration from another employer on the basis of an employment contract, including an employer based outside Poland.
Level: Excellent
Research Field: Biological sciences » Biology
Additional Information
Eligibility criteria
- Creativity measured by the quality and number of scientific publications in which the candidate is the first author, corresponding author, or significant author, and patent applications / patents and / or implementations,
- Mobility in scientific career (including academic internships, change of scientific profile, internships and work in industry),
- Number of citations of the candidate's works, especially those in which the candidate is the first author, corresponding or significant author,
- Creativity measured by the quality and number of research projects,
- Opinion of an independent researcher (R3),
- Any breaks in the scientific work and indicated achievements of the candidate converted into effective years of scientific work,
- Experience in cell culture and working with animals.
Selection process
Up to 30 days from the deadline for submitting documents.
Selected candidates will be invited for an interview. Each of the submitted candidates will receive individual information about the results of the competition in relation to their person. Information on the winner of the competition will be provided on the Institute's website.
Work Location(s)
Number of offers available: 1
Company/Institute: Institute of Human Genetics PAS
Country: Poland
State/Province: Wielkopolska
City: Poznan
Postal Code: 60-479
Street: Strzeszyńska 32
Contact
City: Poznań
Website: http://www.igcz.poznan.pl/
Street: Strzeszyńska 32
Postal Code: 60-479
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