"Research Assistant (Fixed Term)"

We are seeking a bright and enthusiastic research assistant to join the Spatial Profiling and Annotation Centre of Excellence (SPACE), led by Prof. Gregory Hannon and Dr. Dario Bressan, at the CRUK Cambridge Institute, University of Cambridge. This role will involve contributing to the laboratory's research activities by developing and performing assays from the field of histology and spatial "omics" (with a focus on spatial transcriptomics and multi-omics) on tumour clinical samples and tumour models, as well as contributing to the development of new technologies and models in that field. This exciting position will open as a new collaboration between SPACE and the Mair lab to explore the mechanisms of low to high grade transformation in IDH mutant glioma using patient-derived samples, animal models, and a multi-omic spatial approach.

The SPACE centre of excellence is a multidisciplinary group focused on improving spatial molecular profiling technologies (spatial proteomics, transcriptomics, genomics) and applying them to big problems in cancer biology and beyond, through large collaborations within and outside of Cambridge. It includes most available spatial omics technologies, as well as a world class data processing centre and a dedicated staff including biologists, technologists and bioinformaticians. The centre was developed following a successful cancer grand challenge project (IMAXT). Some of the projects currently carried out in the centre include the development of a predictor for triple-negative breast cancer response to therapy, work on the impact of ovarian cancer tumour heterogeneity on its metastatic dissemination, and a project focused on investigating low-to-high grade transition in gliomas.

The Hannon group is renowned for its contributions to RNA biology and cancer research, consistently developing innovative tools to tackle cutting-edge questions. The group has established a robust pipeline for 3D spatial characterization of tumours and tissues, amassing unique imaging data paired with spatially and temporally resolved single-cell transcriptomics and proteomics.

The Mair lab will co-host this position and is known for their contribution to brain cancer biology and clinical translation. They run several clinical trials and manage a large biobank of brain cancer samples in Cambridge.

The role holder will work closely with the SPACE team and the Mair lab alongside other collaborating laboratories. Duties will include sample receipt, designing and performing experiments, reporting results, and ensuring a high and consistent level of quality in experimental work. It is envisioned that the role holder could become closely embedded in a particular project carried out within SPACE, with the possibility of engaging in a course of studies at the University of Cambridge (MSc or PhD) in that context if one is offered.

We are looking to recruit an enthusiastic and competent individual with excellent laboratory skills in molecular biology, histology or cell biology. A background in genomics and previous experience in cancer research are desirable. In particular, we encourage applications from candidates with previous experience with in situ technologies such as single molecule FISH, in-situ transcriptomics, multiplexed IHC, or similar. Experience working with mouse models is a plus.

Experience with tissue culture, RNA extraction and purification, histology, microscopy or bioinformatic analysis would be beneficial but are not strictly required. The successful candidate should show initiative and independent thinking, possess excellent communication and organizational skills, and have the ability to work effectively both individually and as part of a diverse team, integrating their work with that of others. Applicants should have a BSc or MSc degree (or equivalent) in a relevant discipline (Biology, Biochemistry, Natural Sciences) as well as a reasonable amount of practical research experience.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

As a member of our team you will have the opportunity to contribute your own ideas to ongoing research activities. We are committed to providing an inclusive and supportive working environment that fosters intellectual curiosity and scientific excellence.

If you have any queries regarding the application process, please contact: mailbox-hr@cruk.cam.ac.uk.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Please quote reference SW46995 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.