"Research Lab Specialist Assoc"

The laboratory of Roger Cone at the Life Sciences Institute is looking for an experienced mammalian cell culture expert with expertise in GPCR pharmacology and drug discovery. Our laboratory is currently funded in part by a sponsored research agreement with Courage Therapeutics to develop best-in-class melanocortin drugs for eating disorders, including obesity and anorexia nervosa. You will focus on mammalian cell culture, pharmacological assays, high throughput screening, and pharmacological data management and analyses using Graph Pad Prism and Excel. You will be involved in peptide drug discovery research, report directly to Dr. Cone and perform the work onsite.

Experimental job responsibilities will include:

• Culture, management, quality control, and storage of mammalian tissue culture cell lines
• Mammalian cell transfection, selection, and characterization
• Polymerase chain reaction
• Pharmacological assays using mammalian cells, including cAMP assays, ERK assays, b-arrestin recruitment assays, and ligand binding assays
• Collect and analyze laboratory samples
• Maintain well-organized, written records of experimental results

Non-experimental job responsibilities will include:

• Collection and management of cell culture and pharmacological datasets using Graphpad Prism and Excel.
• Demonstrate an understanding of acceptable procedures and techniques
• Follow University safety protocols (may include use of combustibles, toxic material, radioactive material, or carcinogens)
• Prepare reagents
• Order supplies and reagents

Bachelor's degree in Biological Sciences, Biochemistry, Molecular Biology or a related discipline

Three (3) years prior laboratory research experience

Three (3) years prior experience with mammalian cell culture

Three (3) years prior designing experiments, analyzing, and presenting data, with training as needed.

One (1) year of training in cell pharmacology

One (1) year of experience in High throughput cell-based screening

One (1) year of DNA preparation and PCR experience

One (1) year of experience with Excel or Graphpad Prism

Benefits at the University of Michigan:

In addition to a career filled with purpose and opportunity, The University of Michigan offers a comprehensive benefits package to help you stay well, protect yourself and your family and plan for a secure future. Benefits include:

• Generous time off
• A retirement plan that provides two-for-one matching contributions
• Many choices for comprehensive health insurance
• Dental and Vision Insurance
• Life insurance
• Long-term disability coverage
• Flexible spending accounts for healthcare and dependent care expenses
• Maternity and Parental Leave

The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks are performed in compliance with the Fair Credit Reporting Act.

The Life Sciences Institute explores biological processes, structures, and functions at the finest scale to create impact on a global scale.

For more information on the Cone laboratory: https://www.lsi.umich.edu/science/our-labs/roger-cone-lab