Postdoctoral Research Associate - Biochemistry

Position Summary

Center for Drug Discovery is seeking a highly motivated postdoctoral researcher to join our multidisciplinary drug discovery team. This role offers a unique opportunity to bridge the gap between academic innovation and "real-world" therapeutic development.

The successful candidate will be responsible for lead optimization of novel protein aggregate degraders, utilizing both proteasome- and autophagosome-targeting modalities. The candidate will receive hands-on training focusing on the enhancement of potency and optimization of drug-like properties (stability, permeability, PK/PD model, etc.). Additionally, the researcher will develop innovative chemical tools and probes to interrogate fundamental biologic processes and mechanism of action.

In addition to high-quality research facilities, career and professional development training for postdoctoral researchers is provided through the Career Center, Teaching Center, Office of Postdoctoral Affairs, and campus groups.

Job Description

Primary Duties & Responsibilities:

Information on being a postdoc at WashU in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/.

Trains under the supervision of a faculty mentor including (but not limited to):

• Synthesizes heterocyclic binders and degraders.
• Troubleshoots multi-step heterocyclic synthesis independently.
• Develops expertise in chemical biology probe design and synthesis.
• Develops expertise in evaluating compounds’ drug-like properties.
• Develops proficiency in career skills, including writing, public speaking, networking, and critical evaluation of scientific literature.
• Presents scientific work both inside and outside the University with excellent oral communication skills.
• Assists with grant preparation and reporting.
• Prepares and submits papers on research.
• Assists in the design of research experiments.
• Evaluates research findings and assists in the reporting of the results.
• Conscientious discharge of their research responsibilities.
• Maintains conformity with ethical standards in research.
• Maintains compliance with good laboratory practice including the maintenance of adequate research records.
• Engages in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
• Collegial conduct towards co-trainees, staff members and members of the research group.
• Adherence to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.

Working Conditions:

This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range:

Base pay is commensurate with experience.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education:

Ph.D., M.D. Or Equivalent Terminal Or Doctoral Degree. - Organic Chemistry

Certifications/Professional Licenses:

No specific certification/professional license is required for this position.

Work Experience:

No specific work experience is required for this position.

Skills:

Not Applicable

Driver's License:

A driver's license is not required for this position.

More About This Job

At WashU, postdoctoral appointments:

• Have a 5-year term limit that includes previous experience. 

Preferred Qualifications

Education:

No additional education unless stated elsewhere in the job posting.

Certifications/Professional Licenses:

No additional certification/professional licenses unless stated elsewhere in the job posting.

Work Experience:

No additional work experience unless stated elsewhere in the job posting.

Skills:

Collaboration, Data Analysis, Data Interpretations, Experimentation, Laboratory Operations, Laboratory Techniques, Researching, Results Reporting, Scientific Writing